Show Prices. The staff is helpful, the rooms are pretty large and breakfast is extensive.
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Thon Hotel Brussels Airport. Berkenlaan 4 , Diegem, Machelen , Belgium.
Rijckendael Hotel. Even with certain duscounts, it is a bit expensive doe what you get. I think the owner Campanile Valenciennes Ouest - Petite Foret. Our little dog was realy welcom Nice lounge , confortable bed and nice shower.
Emplacement very quiet. Breakfast buffet contrains cheese, ham, boter Quiet in spite of location near motorway and large shopping centre. Clean rooms and good breakfast for an Ibis Budget. Easy to book online. Can fill up on day so book Van der Valk Brussels Airport. Culliganlaan 4B , Diegem, Machelen , Belgium. Free parking. Close to airport, use it every time when flight times are no so sleep friendly. Room was big and clean.
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I love the customer service and hotel common rooms. NH Brussels Airport. Nice clean rooms with everything you need. We got a little bottle of apple juice and a dry Taking safety measures. Special offer. Visit hotel website. Pegasus Apparthotel Brussels Expo. Oude Mechelsestraat 71 , Strombeek-Bever , Belgium. Hotel Taormina. Leuvensesteenweg , Zaventem , Belgium. The orders were partially brought etc The restaurant was ok but expensive for what they offer.
The room was by the street.. A lot of noise Crowne Plaza Hotel Brussels Airport. Leonardo da Vincilaan 4 , Diegem, Machelen , Belgium. The rooms are very comfortable and good quality. Check in staff is friendly and helpful. All covid measures are in place and followed Chateau d'Aubry. There was none in the English section but we decided to stick with it and Novotel Brussels Airport. Participants were randomly assigned by chance, like flipping a coin to one of the two treatment groups-which will remain undisclosed to the participant and study doctor during the study unless there is an urgent medical need : Ixazomib citrate 3 mg for the first 4 cycles, then 4 mg for the remaining 22 cycles Placebo dummy inactive pill - this is a capsule that looks like the study drug but has no active ingredient.
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FDA Resources. Arms and Interventions. Ixazomib citrate placebo-matching capsules, orally, once on Days 1, 8 and 15 in a day cycle for Cycles 1 through 26 until PD, unacceptable toxicity, or discontinuation for alternate reasons. Outcome Measures. Response was assessed according to IMWG criteria.
PFS2 is defined as the time from the date of randomization to the date of objective disease progression on next line treatment or death from any cause whichever occurs first.
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Time to start of the next line of therapy was defined as the time from the date of randomization to the date of initiation dose of the next line of antineoplastic therapy following study treatment or death due to any cause, whichever occurs first. Time to end of the next line of therapy is defined as the time from the date of randomization to the date of last dose of the next line of antineoplastic therapy following study treatment or death due to any cause, whichever occurs first. Duration of the next line of therapy is defined as the time from the date of the first dose of the next line of therapy to the date of the last dose of the next antineoplastic therapy following study treatment or death due to any cause, whichever occurs first.
Degree of correlation will be determined between 2 methodologies for MRD assessment 8-color flow cytometry, next-generation sequencing and bone marrow aspirates and blood samples. High-risk population will include but not be limited to participants carrying deletion del 17, t , t , amplification ampl 1q, del13, or del1p.
The ECOG performance is a 6-point scale used by doctors to assess how a participant's disease is progressing, how the disease affects the participant's daily life, and to determine appropriate treatment and prognosis. Peripheral neuropathy is defined as the treatment-emergent adverse event in the high-level term of peripheral neuropathies not elsewhere classified NEC according to Medical Dictionary for Regulatory Activities MedDRA.
Eligibility Criteria. Information from the National Library of Medicine Choosing to participate in a study is an important personal decision. Inclusion Criteria: Adult male or female participants 18 years or older with a confirmed diagnosis of symptomatic multiple myeloma according to standard criteria. Vincristine, Adriamycin [doxorubicin], and dexamethasone VAD is not an acceptable induction therapy for this trial. Started screening no earlier than 75 days after transplant, completed screening within 15 days, and randomized no later than days after transplant.
Must have not received post-ASCT consolidation therapy. ECOG performance status of 0 to 2. Female participants who: If they are of childbearing potential, agree to practice 2 effective methods of contraception, at the same time, from the time of signing the informed consent through 90 days after the last dose of study drug, AND Must also adhere to the guidelines of any treatment-specific pregnancy prevention program, if applicable, OR Agree to practice true abstinence, when this is in line with the preferred and usual lifestyle of the participant.
Periodic abstinence [eg, calendar, ovulation, symptothermal, postovulation methods for the female partner] and withdrawal are not acceptable methods of contraception. Male participants, even if surgically sterilized ie, status postvasectomy , who: Agree to practice effective barrier contraception during the entire study treatment period and through 90 days after the last dose of study drug, AND Must also adhere to the guidelines of any treatment-specific pregnancy prevention program, if applicable, OR Agree to practice true abstinence, when this is in line with the preferred and usual lifestyle of the participant.
Voluntary written consent must be given before performance of any study-related procedure not part of standard medical care, with the understanding that consent may be withdrawn by the participant at any time without prejudice to future medical care. Suitable venous access for the study-required blood sampling.
Is willing and able to adhere to the study visit schedule and other protocol requirements.
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Platelet transfusions to help participants meet eligibility criteria are not allowed within 3 days before randomization. Exclusion Criteria: Multiple myeloma which has relapsed following primary therapy or is not responsive to primary therapy. For this study, stable disease following ASCT will be considered nonresponsive to primary therapy. Double tandem ASCT. Radiotherapy within 14 days before the first dose of study drug. Diagnosed or treated for another malignancy within 5 years before randomization or previously diagnosed with another malignancy with evidence of residual disease.
Participants with nonmelanoma skin cancer or carcinoma in situ of any type are not excluded if they have undergone complete resection. Female participants who are lactating and breastfeeding or have a positive serum pregnancy test during the Screening period. Major surgery within 14 days before randomization. Central nervous system involvement. Infection requiring intravenous IV antibiotic therapy or other serious infection within 14 days before randomization. Diagnosis of Waldenstrom's macroglobulinemia, POEMS polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes syndrome, plasma cell leukemia, primary amyloidosis, myelodysplastic syndrome, or myeloproliferative syndrome.
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